期刊
HUMAN BRAIN MAPPING
卷 30, 期 12, 页码 3981-3992出版社
WILEY
DOI: 10.1002/hbm.20823
关键词
aging; medial temporal lobe; cingulate gyrus; cognition; frontal lobe; Alzheimer's disease
资金
- NIH [PO1-AG024831, AG13308, P50-AG16570, MH/AG58156, MH52453, AG10123, M01RR00865]
- Department of Energy [DE-FC03-87-ER60615]
- General Clinical Research Centers Program
- Rotary CART Fund
- Alzheimer's Association
- Fran and Ray Stark Foundation Fund for Alzheimer's Disease Research
- Ahmanson Foundation
- Larry L. Hillbiom Foundation
- Lovelace Foundation
- Judith Clenick Elgart Fund for Research on Brain Aging
- John Douglas French Alzheirner's Foundation
- Tamkin Foundation
Entorhinal cortex (ERC) volume in adults with mild cognitive impairment has been shown to predict prodromal Alzheimer's disease (AD). Likewise, neuronal loss in ERC has been associated with AD, but not with normal aging. Because ERC is part of a major pathway modulating input to the hippocampus, structural changes there may result in changes to cognitive performance and functional brain activity during memory tasks. In 32 cognitively intact older adults, we examined the relationship between left ERC thickness and functional magnetic resonance imaging (WRI) activity during an associative verbal memory task. This task has been shown previously to activate regions that are sensitive to aging mid AD risk. ERC was manually defined on native space, high resolution, oblique coronal MRI scans. Subjects having thicker left ERC showed greater activation in anterior cingulate and medial frontal regions during memory retrieval, but not encoding. This result was independent of hippocampal volume. Anterior cingulate cortex is directly connected to ERC, and is, along with medial frontal cortex, implicated in error detection, which is impaired in AD. Our results suggest that in healthy older adults, processes that engage frontal regions during memory retrieval are related to ERC structure. Hum Brain Mapp 30:3981-3992, 2009. (C) 2009 Wiley-Liss, Inc.
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