期刊
HUMAN BRAIN MAPPING
卷 30, 期 9, 页码 2986-2996出版社
WILEY
DOI: 10.1002/hbm.20723
关键词
EEG-fMRI; epilepsy; independent component analysis
In this study, we introduce a new approach to process simultaneous Electroencephalography and functional Magnetic Resonance Imaging (EEG-fMRI) data in epilepsy. The method is based on the decomposition of the EEG signal using independent component analysis (ICA) and the usage of the relevant components' time courses to define the event related model necessary to find the regions exhibiting fMRI signal changes related to interictal activity. This approach achieves a natural data-driven differentiation of the role of distinct types of interictal activity with different amplitudes and durations in the epileptogenic process. Agreement between the conventional method and this new approach was obtained in 6 out of 9 patients that had interictal activity inside the scanner. In all cases, the maximum Z-score was greater in the fMRI studies based on ICA component method and the extent of activation was increased in 5 out of the 6 cases in which overlap was found. Furthermore, the three cases where an agreement was not found were those in which no significant activation was found at all using the conventional approach. Hum Brain Mapp 30:2986-2996, 2009. (C) 2009 Wiley-Liss, Inc.
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