期刊
HUMAN BRAIN MAPPING
卷 30, 期 4, 页码 1290-1309出版社
WILEY
DOI: 10.1002/hbm.20597
关键词
visual evoked response; retinotopy; inverse; MEG; EEG; fMRI
资金
- NIBIB NIH HHS [R01 EB000790] Funding Source: Medline
- NIMH NIH HHS [K01 MH079146] Funding Source: Medline
- NINDS NIH HHS [R01 NS018741-25, R01 NS018741] Funding Source: Medline
Studying the human Visual system with high temporal resolution is a significant challenge due to the limitations of the available, noninvasive measurement tools. MEG and EEG provide the millisecond temporal resolution necessary for answering questions about intracortical communication involved in visual processing, but source estimation is ill-posed and unreliable when multiple; simultaneously active areas are located close together. To address this problem, we have developed a retinotopy-constrained source estimation method to calculate the time courses of activation in multiple visual areas. Source estimation was disambiguated by: (1) fixing MEG/EEG generator locations and orientations based on fMRI retinotopy and surface tessellations constructed from high-resolution MRI images; and (2) solving for many visual field locations simultaneously in MEG/EEG responses, assuming source current amplitudes to be constant or varying smoothly across the Visual field. Because of these constraints on the solutions, estimated Source waveforms become less sensitive to sensor noise or random errors in the specification of the retinotopic dipole models. We demonstrate the feasibility of this method and discuss future applications such as studying the timing of attentional modulation in individual visual areas. Hum Brain Mapp 30:1290-1309, 2009. (C) 2008 Wiley-Liss. Inc.
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