期刊
HORMONES AND BEHAVIOR
卷 65, 期 5, 页码 505-515出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2014.03.017
关键词
Mild cognitive impairment; Alzheimer's disease; SAMP8; Testosterone; Dihydrotestosterone
资金
- National Natural Science Foundation of China [31271191]
- Natural Science Foundation of Hebei Province [C2009001081, C2012206128]
The senescence-accelerated-prone mouse 8 (SAMP8) has been proposed as a suitable, naturally derived animal model for Alzheimer's disease (AD). In the current study, we focus on the problem whether SAMP8 mice show abnormal behavioral and neuropathological signs before they present the characteristic of AD. Our results demonstrated that given the presence of the senescent, behavioral and neuropathological characteristics, the middle-aged SAMP8 mice appear to be a suitable and naturally derived animal model for MCI basic research. There is relatively less evidence that androgen may be involved in the pathogenesis of AD. We determined testosterone (T) levels of SAMR1 and SAMP8 mice and found that the marked age-related decrease in serum androgen levels may be one of the risk factors for Alzheimer's dementia. We also evaluated the interventional effect on MCI phase by dihydrotestosterone (DHT) in male SAMP8 mice and found that timely and appropriate androgen intervention can postpone the onset and improve the symptoms of dementia. (C) 2014 Elsevier Inc. All rights reserved.
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