期刊
HORMONES AND BEHAVIOR
卷 65, 期 1, 页码 57-65出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2013.11.005
关键词
Mandarin vole (Microtus mandarinus); Paternal deprivation; Social recognition; Medial amygdala; Nucleus accumbens; Oxytocin receptor; Estrogen receptor alpha
资金
- National Natural Science Foundation of China [31372213, 31170377]
- Fundamental Research Funds for the Central Universities [GK201305009]
- Innovation Funds of Graduate Programs, Shaanxi Normal University [2013CXB010]
Paternal care is necessary for the healthy development of social behavior in monogamous rodents and social recognition underpins social behavior in these animals. The effects of paternal care on the development of social recognition and underlying neuroendocrine mechanisms, especially the involvement of oxytocin and estrogen pathways, remain poorly understood. We investigated the effects of paternal deprivation (PD: father was removed from neonatal pups and mother alone raised the offspring) on social recognition in mandarin voles (Microtus mandarinus), a socially monogamous rodent. Paternal deprivation was found to inhibit the development of social recognition in female and male offspring according to a habituation-dishabituation paradigm. Paternal deprivation resulted in increased inactivity and reduced investigation during new encounters with other animals. Paternal deprivation reduced oxytocin receptor (OTR) and estrogen receptor alpha (ER alpha) mRNA expression in the medial amygdala and nucleus accumbens. Paternal deprivation reduced serum oxytocin (OT) concentration in females, but had no effect on males. Our results provide substantial evidence that paternal deprivation inhibits the development of social recognition in female and male mandarin voles and alters social behavior later in life. This is possibly the result of altered expression of central OTR and ER alpha and serum OT levels caused by paternal deprivation. (C) 2013 Elsevier Inc. All rights reserved.
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