期刊
HORMONES AND BEHAVIOR
卷 63, 期 3, 页码 411-417出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2012.11.010
关键词
Maternal separation; Early handling; Maternal care; Postnatal development; c57bl/6 mouse; Corticosterone; Early life stress; Anxiety; HPA axis
资金
- Pritzker Neuropsychiatric Disorders Research Consortium
- Pritzker Neuropsychiatric Disorders Research Fund L.L.C.
- NARSAD Young Investigator Grant [N008728]
Adverse early life experience, such as childhood abuse, neglect, and trauma, increases lifetime risk for mental illness. To investigate underlying mechanisms, the maternal separation (MS) paradigm was developed and validated as an animal model of early adversity in rats, reliably effecting long-term changes to anxiety, gene expression, and stress response. However, across-species validation of core findings in mice has met with limited success. To re-visit parameters governing the effectiveness of MS in mice, this study investigated the effect of MS on maternal care, offspring behavior, and offspring stress-induced corticosterone response in the c57bl/6 mouse strain. The results from this study suggest that: (i) levels of maternal care increase as a function of separation duration immediately after daily MS, but long-term care remains unchanged; and (ii) c57bl/6 mice are resilient to MS, exhibiting subtle decreases in anxiety and unchanged stress-induced corticosterone response as adults, irrespective of separation duration. (c) 2012 Elsevier Inc. All rights reserved.
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