期刊
HORMONES AND BEHAVIOR
卷 53, 期 5, 页码 716-728出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2008.01.014
关键词
androgens; motoneurons; peripheral nerve injury; spinal cord injury; motoneuron disease; gonadal steroids
资金
- NINDS NIH HHS [R01 NS028238-11, R01 NS028238, R01 NS028238-12, F32 NS052997, R01 NS028238-12S1, R01 NS028238-11S1, F32 NS052997-02, R01 NS028238-13, F32 NS052997-01A1] Funding Source: Medline
Androgens act on the CNS to affect motor function through interaction with a widespread distribution of intracellular androgen receptors (AR). This review highlights our work on androgens and process outgrowth in motoneurons, both in vitro and in vivo. The actions of androgens on motoneurons involve the generation of novel neuronal interactions that are mediated by the induction of androgen-dependent neurite or axonal outgrowth. Here, we summarize the experimental evidence for the androgenic regulation of the extension and regeneration of motoneuron neurites in vitro using cultured immortalized motoneurons, and axons in vivo using the hamster facial nerve crush paradigm. We place particular emphasis on the relevance of these effects to SBMA and peripheral nerve injuries. (c) 2008 Elsevier Inc. All rights reserved.
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