期刊
HORMONES AND BEHAVIOR
卷 53, 期 1, 页码 159-169出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2007.09.011
关键词
estradiol; cholinergic system; verbal memory; critical period
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000109] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021476, F32AG023430] Funding Source: NIH RePORTER
- NCRR NIH HHS [M01 RR000109-420594, M01 RR000109] Funding Source: Medline
- NIAAA NIH HHS [AA IIRG 99-1811] Funding Source: Medline
- NIA NIH HHS [F32 AG023430-02, R01 AG021476, R01 AG021476-05, F32 AG023430] Funding Source: Medline
- PHS HHS [NCRR-00109] Funding Source: Medline
Estradiol has been shown to interact with the cholinergic system to affect cognition in postmenopausal women. This study further investigated the interaction of estradiol and cholinergic system functioning on verbal memory and attention in two groups of healthy younger (ages 50-62) and older (ages 70-81) postmenopausal women. Twenty-two postmenopausal women were randomly and blindly placed on 1 mg of 17-beta estradiol orally for 1 month then 2 mg for 2 months or matching placebo pills after which they participated in three anticholinergic challenge sessions when verbal memory and attention were assessed. Subjects were administered either the antimuscarinic drug scopolamine (SCOP), the antinicotinic drug mecamylamine (MECA), or placebo. After the first challenge phase, they were crossed over to the other hormone treatment for another 3 months and repeated the challenges. Results showed that estradiol pretreatment significantly attenuated the anticholinergic drug-induced impairments on a test of episodic memory (the Buschke Selective Reminding Task) for the younger group only, while estradiol treatment impaired performance of the older group. The results suggest that younger subjects may experience more cholinergic benefit from estradiol treatment than older subjects, supporting the concept of a critical period for postmenopausal estrogen use. (c) 2007 Elsevier Inc. All rights reserved.
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