期刊
HORMONE AND METABOLIC RESEARCH
卷 41, 期 8, 页码 626-629出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1216359
关键词
adipokines; follow-up studies; haemoglobin A; glycosylated; C-reactive protein
资金
- Medical Research Council
- Wingate Foundation
- Economic and Social Research Council
- British Heart Foundation
- Health and Safety Executive
- Department of Health
- National Heart Lung and Blood Institute [HL36310]
- NIH: National Institute on Aging [AG13196]
- NIH
- Agency for Health Care Policy Research [HS06516]
- John D and Catherine T. MacArthur Foundation
- MRC [G0501184] Funding Source: UKRI
- British Heart Foundation [RG/07/008/23674] Funding Source: researchfish
- Medical Research Council [G0100222, G0501184, G8802774, G19/35] Funding Source: researchfish
Our aim of the present work was to study the effect of serum adiponectin on incident diabetes and HbA1c values. We measured baseline serum adiponectin levels in a nested case-control selection (n = 140) of the Whitehall 11 Cohort. Participants (mean [SD] age 50.9 [6.3] years) had no prevalent diabetes or CHD at baseline. Cases (n=55) had incident diabetes according to an oral glucose tolerance test during follow-up (mean: 11.5 +/- 3.0 years). Adiponectin levels were lower among cases (9.3 mu g/ml, 3.2 [median; IQR] vs. 10.5; 3.6, p=0.01). The risk of incident diabetes decreased by 11% (p=0.03) for 1 mu g/ml higher adiponectin levels. Higher adiponectin levels were associated with lower HbA1c at follow-up (p<0.05). Both associations were stable to adjustment for age, sex, body mass index, systolic blood pressure, and serum lipids, and for the case of HbA1c, also for C-reactive protein (all p<0.05). The observed robust, prospective associations support that adiponectin is an independent predictor of diabetes and the degree of glycaemic impairment.
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