期刊
LANGMUIR
卷 31, 期 46, 页码 12777-12782出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.5b03470
关键词
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资金
- Ministerio de Economia y Competitividad [MAT2012-35556, MAT2013-43299R, CSO2010-11384-E]
- ERC [239931]
- Fondo Social Europeo (FSE
- Gobierno de Aragon)
- VI National RDi Plan
- Iniciativa Ingenio
- Consolider Program
- CIBER Actions
- Instituto de Salud Carlos III
- European Regional Development Fund
- CEI Campus Moncloa
- European Research Council (ERC) [239931] Funding Source: European Research Council (ERC)
Magnetically triggered drug delivery nanodevices have attracted great attention in nanomedicine, as they can feature as smart carriers releasing their payload at clinician's will. The key principle of these devices is based on the properties of magnetic cores to generate thermal energy in the presence of an alternating magnetic field. Then, the temperature increase triggers the drug release. Despite this potential, the rapid heat dissipation in living tissues is a serious hindrance for their clinical application. It is hypothesized that magnetic cores could act as hot spots, this is, produce enough heat to trigger the release without the necessity to increase the global temperature. Herein, a nanocarrier has been designed to respond when the temperature reaches 43 degrees C. This material has been able to release its payload under an alternating magnetic field without the need of increasing the global temperature of the environment, proving the efficacy of the hot spot mechanism in magnetic-responsive drug delivery devices.
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