期刊
LANGMUIR
卷 31, 期 18, 页码 5123-5129出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.5b00654
关键词
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资金
- DTRA [HDTRA1-12-1-0039]
- Army Research Office (ARO) [W911NF-11-1-0251]
- Whitaker International Scholars Program
- Scientific and Technical Research Council of Turkey (TUBITAK) [2219]
We use chemical vapor deposition polymerization to prepare a novel dibromomaleimide-functionalized polymer for selective and reversible binding of thiol-containing biomolecules on a broad range of Substrates. We report the synthesis and CVD polymerization of 4-(3,4-dibromomaleimide)[2.2]paracyclophane to yield nanometer thick polymer coatings. Fourier transformed infrared spectroscopy and X-ray photoelectron spectroscopy confirmed the chemical composition of the polymer coating. The reactivity of the polymer coating toward thiol-functionalized molecules was confirmed using fluorescent ligands. As a proof of concept, the binding and subsequent release of cysteine-modified peptides from the polymer coating were also demonstrated via sum frequency generation spectroscopy. This reactive polymer coating provides a flexible surface modification approach to selectively and reversibly bind biomolecules on a broad range of materials, which Could open up new opportunities in many biomedical sensing and diagnostic applications where specific binding and release of target analytes are desired.
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