期刊
HIV MEDICINE
卷 16, 期 1, 页码 48-56出版社
WILEY
DOI: 10.1111/hiv.12171
关键词
antiretroviral therapy; CD4 T-cell recovery; chloroquine; HIV; Toll-like receptors
资金
- CIHR Canadian HIV Trials Network [CTN 246]
- Research Institute of the McGill University Health Centre
- Ontario HIV Treatment Network Career Scientist Award
- CANFAR/CTN Postdoctoral Fellowship Award
ObjectivesChloroquine (CQ), an anti-inflammatory drug, inhibits Toll-like receptor (TLR) signalling in plasmacytoid dendritic cells (pDCs) and may be beneficial for HIV-infected patients in whom immune activation persists despite effective antiretroviral therapy (ART). The effect of CQ on CD4 T-cell recovery and immune activation in immune nonresponding patients receiving successful ART was therefore studied. MethodsNineteen adults on ART with CD4 counts 350cells/L and undetectable viral load (VL) orally received CQ at 250mg/day for 24 weeks. Side effects, CD4 and CD8 T-cell counts, VL, T-cell activation, pDC proportion and plasma inflammatory markers were assessed at baseline, at 24 weeks, and at 12 weeks after CQ discontinuation (clinicaltrial.org registration #NCT02004314). ResultsCQ was well tolerated and all patients maintained an undetectable VL. The absolute CD4 and CD8 T-cell counts and their percentages, the pDC proportion, T-cell activation, D-dimer and C-reactive protein (CRP) plasma levels and the kynurenine/tryptophan ratio did not change with CQ treatment. Among nine cytokines/chemokines measured, only levels of interferon (IFN)-2 were significantly increased by CQ treatment. ConclusionsCQ was well tolerated in patients with low CD4 T-cell counts despite long-term effective ART; however, 24 weeks of CQ treatment did not improved CD4 T-cell recovery, lymphoid and myeloid immune activation or inflammatory markers.
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