期刊
HISTOPATHOLOGY
卷 64, 期 7, 页码 921-934出版社
WILEY
DOI: 10.1111/his.12341
关键词
carbonic anhydrase IX; gallbladder neoplasms; neoplasm metastasis; paxillin; prognosis
资金
- Department of Pathology, Basic School of Medicine
- Department of Pathology, Second Xiangya Hospital
- Department of Pathology, Third Xiangya Hospital
- Department of Pathology, Loudi Central Hospital
- Department of Pathology, Hunan Provincial Tumour Hospital
AimsSquamous cell/adenosquamous carcinomas (SC/ASC) are rare subtypes of gallbladder cancers (GBCs). Clinical characteristics of SC/ASC have not been well documented, and no biological markers of GBC carcinogenesis, progression and prognosis are available. Methods and resultsWe measured paxillin and CAIX expression in 46 SC/ASCs and 80 adenocarcinomas (ACs) with immunohistochemistry and correlated these data with clinicopathological characteristics. Both paxillin expression and CAIX expression were associated significantly with larger tumours, a higher tumour-node-metastasis (TNM) stage, lymph node metastasis and invasiveness of SC/ASC and AC. Univariate Kaplan-Meier analysis confirmed that paxillin and CAIX expression were associated closely with decreased overall survival in SC/ASC (both P<0.001) and AC (both P<0.001). Multivariate Cox regression analysis confirmed that paxillin expression and CAIX expression both independently predicted poor prognosis in SC/ASC and AC patients. We also noted correlations with survival and tumour differentiation, tumour size, TNM stage, lymph node metastasis, tumour invasiveness and sample procurement methods. ConclusionsPaxillin expression and CAIX expression are both related to clinical/biological behaviour and poor prognosis of GBC.
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