期刊
HISTOPATHOLOGY
卷 53, 期 2, 页码 205-217出版社
WILEY
DOI: 10.1111/j.1365-2559.2008.03076.x
关键词
Bcl-2; Bcl-6; chromosome translocation; diffuse large B cell lymphoma; MYC
资金
- Tumour Immunity Medical Research Centre at Seoul National University College of Medicine
- Seoul National University Hospital Research Fund [04-2006-060-0]
Aims: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with various genetic alterations. The aim was to investigate MYC, Bcl-2 and Bcl-6 translocations and copy number changes adult DLBCLs to evaluate their clinicopathological features and prognostic implications. Methods and results: Gene status was examined using fluorescence situ hybridization (FISH), and the results were analysed in the context of germinal centre B-cell (GCB) and non-GCB type of DLBCL based on immunohistochemistry. MYC translocation was observed in 9% (14 of 156), and an increased copy number (ICN) in 7.1% (11 of 156). MYC translocation was more common in GCB type (22%)) than in non-GCB type (4.9%), and associated with advanced International Prognostic Index (IPI). MYC aberration, i.e. translocation or increased copy number (ICN), was significantly associated with shorter overall survival, especially for the GCB type. Bcl-2 translocation was rare (3.4%. five of 145), and ICN was observed in 11.7%, (1.7 of 145). more frequently in non-GCB type (16%) than in GCB type (2.5%). Bcl-2 aberration tended to have an adverse effect on Survival. In multivariate analysis, MYC ICN was an independent poor prognostic factor. Conclusions: Analyses of MYC and Bcl-2 status. i.e. translocation and ICN, in the context of DLBCL phenotype might help predict prognosis and therapeutic strategies.
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