期刊
HISTOPATHOLOGY
卷 52, 期 3, 页码 305-313出版社
WILEY
DOI: 10.1111/j.1365-2559.2007.02950.x
关键词
chromogranin A; neuroendocrine differentiation; prognosis; signet ring cell carcinoma; stomach
Aims: To investigate neuroendocrine (NE) differentiation in gastric signet ring cell carcinoma (SRCC) using chromogranin A (CgA) as an indicator of a well-differentiated NE phenotype and to determine its relationship to cell type, stage and prognosis. Methods and results: 102 SRCCs were categorized into five subtypes according to the predominant cell type in the World Health Organization classification. 38 cases (37.3%) showed focal or diffuse CgA positivity. The positive cells were mostly histiocytoid and eosinophilic SRCC cells and some were classical SRCC cells. Small cell and anaplastic-type SRCC cells were only rarely immunopositive. There was no significant relationship between CgA expression and the extent of invasion or presence of metastasis. However, a significant positive correlation existed between CgA positivity and favourable prognosis, with a tendency for greater positivity to be associated with better overall survival. Multivariate analysis showed expression of CgA to be an independent prognostic factor. Conclusions: CgA expression is restricted to certain tumour cell types and may help to predict prognosis in gastric SRCCs.
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