期刊
LANGMUIR
卷 31, 期 22, 页码 6027-6034出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.5b01129
关键词
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资金
- Midcareer Researcher Program through the National Research Foundation (NRF) - MSIP [2014R1A2A2A01005813]
- Industrial Strategic Technology Development Program of the Korea Evaluation Institute of Industrial Technology (KEIT) - MOTIE [10045068]
- Research and Development Program of the Korea Institute of Energy Research (KIER) [B4-2434-01]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10045068] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2014R1A2A2A01005813] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Semipermeable microcapsules are appealing for controlled release of drugs, study of cell-to-cell communication, and isolation of enzymes or artificial catalysts. Here, we report a microfluidic strategy for creating monodisperse microcapsules with size-selective permeability using polymerization-induced phase separation. Monodisperse water-in-oil-in-water (W/O/W) double-emulsion drops, whose ultrathin middle layer is composed of photocurable resin and inert oil, are generated in a capillary microfluidic device, and irradiated by UV light. Upon UV illumination, the monomers are photopolymerized, which leads to phase separation between the polymerized resin and the oil within the ultrathin shell. Subsequent dissolution of the oil leaves behind regular pores in the polymerized membrane that interconnect the interior and exterior of the microcapsules, thereby providing size-selective permeability. The degree of phase separation can be further tuned by adjusting the fraction of oil in the shell or the affinity of the oil to the monomers, thereby enabling the control of the cutoff value of permeation. High mechanical stability and chemical resistance of the microcapsules, as well as controllable permeability and high encapsulation efficiency, will provide new opportunity in a wide range of applications.
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