期刊
HISTOCHEMISTRY AND CELL BIOLOGY
卷 140, 期 2, 页码 93-104出版社
SPRINGER
DOI: 10.1007/s00418-013-1127-4
关键词
Mass spectrometry imaging; Quantitation; Drug; Metabolite; In situ; High resolution
资金
- BMBF [0315508A, 01IB10004E]
- Deutsche Forschungsgemeinschaft [SFB 824 TP B1, SFB 824 TP Z2, WA 1656/3-1]
Mass spectrometry imaging (MSI) is a rapidly evolving technology that yields qualitative and quantitative distribution maps of small pharmaceutical-active molecules and their metabolites in tissue sections in situ. The simplicity, high sensitivity and ability to provide comprehensive spatial distribution maps of different classes of biomolecules make MSI a valuable tool to complement histopathology for diagnostics and biomarker discovery. In this review, qualitative and quantitative MSI of drugs and metabolites in tissue at therapeutic levels are discussed and the impact of this technique in drug discovery and clinical research is highlighted.
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