期刊
HISTOCHEMISTRY AND CELL BIOLOGY
卷 140, 期 3, 页码 271-283出版社
SPRINGER
DOI: 10.1007/s00418-013-1117-6
关键词
COG; Golgi; SNARE; Rab; Tether; Membrane trafficking
资金
- National Institute of Health [1R01GM083144]
- BBSRC [BB/F006993/1/]
- Marie Curie grant [201098]
- BBSRC [BB/F006993/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F006993/1] Funding Source: researchfish
The central organelle within the secretory pathway is the Golgi apparatus, a collection of flattened membranes organized into stacks. The cisternal maturation model of intra-Golgi transport depicts Golgi cisternae that mature from cis to medial to trans by receiving resident proteins, such as glycosylation enzymes via retrograde vesicle-mediated recycling. The conserved oligomeric Golgi (COG) complex, a multi-subunit tethering complex of the complexes associated with tethering containing helical rods family, organizes vesicle targeting during intra-Golgi retrograde transport. The COG complex, both physically and functionally, interacts with all classes of molecules maintaining intra-Golgi trafficking, namely SNAREs, SNARE-interacting proteins, Rabs, coiled-coil tethers, vesicular coats, and molecular motors. In this report, we will review the current state of the COG interactome and analyze possible scenarios for the molecular mechanism of the COG orchestrated vesicle targeting, which plays a central role in maintaining glycosylation homeostasis in all eukaryotic cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据