期刊
HISTOCHEMISTRY AND CELL BIOLOGY
卷 140, 期 4, 页码 407-421出版社
SPRINGER
DOI: 10.1007/s00418-013-1138-1
关键词
CtBP1/BARS; Membrane fission; Golgi complex; Golgi checkpoint; Mitosis; ADP ribosylation
资金
- Italian Association for Cancer Research [IG10341, IG4700]
- Legge [46/82]
- FaReBio, Ministry of Economy and Finance, MIUR [PON01-00117, PON01-00862]
- PNR-CNR Aging Program
- Italian Foundation for Cancer Research Fellowships (FIRC, Milan, Italy)
- [FIT DM 24/09/2009]
- Fondazione Telethon Funding Source: Custom
The brefeldin A ADP-ribosylated substrate, a member of the C-terminal-binding protein family that is referred to as CtBP1/BARS, is a dual-function protein that acts as a transcriptional co-repressor in the nucleus and as an inducer of membrane fission in the cytoplasm. In this review, we first discuss the mechanisms that enable CtBP1/BARS to shift between the nuclear transcriptional co-repressor and the cytosolic fission-inducing activities. Then, we focus on the role of CtBP1/BARS in membrane fission. CtBP1/BARS controls several fission events including macropinocytosis, fluid-phase endocytosis, COPI-coated vesicle formation, basolaterally directed post-Golgi carrier formation, and Golgi partitioning in mitosis. We report on recent advances in our understanding of the CtBP1/BARS membrane fission machineries that operate at the trans-side and at the cis-side of the Golgi complex. Specifically, we discuss how these machineries are assembled and regulated, and how they operate in the formation of the basolaterally directed post-Golgi carriers.
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