期刊
HISTOCHEMISTRY AND CELL BIOLOGY
卷 140, 期 1, 页码 13-22出版社
SPRINGER
DOI: 10.1007/s00418-013-1101-1
关键词
Intermediate filaments; Neurodegenerative disease; Glioma
资金
- AFM (Association Francaise contre les Myopathies)
- ARC (Association de Recherche sur le Cancer)
- CIMATH (Ciblage Moleculaire et Applications Therapeutiques)
- Ministere de la Recherche
- INSERM (Institut National de la Sante et de la Recherche Medicale)
Intermediate filaments (IFs) of the nervous system, including neurofilaments, alpha-internexin, glial fibrillary acidic protein, synemin, nestin, peripherin and vimentin, are finely expressed following elaborated cell, tissue and developmental specific patterns. A common characteristic of several neurodegenerative diseases is the abnormal accumulation of neuronal IFs in cell bodies or along the axon, often associated with impairment of the axonal transport and degeneration of neurons. In this review, we also present several perturbations of IF metabolism and organization associated with neurodegenerative disorders. Such modifications could represent strong markers of neuronal damages. Moreover, recent data suggest that IFs represent potential biomarkers to determine the disease progression or the differential stages of a neuronal disorder. Finally, recent investigations on IF expression and function in cancer provide evidence that they may be useful as markers, or targets of brain tumours, especially high-grade glioma. A better knowledge of the molecular mechanisms of IF alterations, combined to neuroimaging, is essential to improve diagnosis and therapeutic strategies of such neurodegenerative diseases and glioma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据