期刊
HIPPOCAMPUS
卷 29, 期 2, 页码 63-67出版社
WILEY
DOI: 10.1002/hipo.22998
关键词
Binding; Medial Temporal Lobe; Short term memory
资金
- Wellcome Trust
- Wellcome Trust [203130/Z/16/Z]
- Wellcome Centre for Integrative Neuroimaging, Oxford
- University of Oxford
- NIHR Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust
- British Academy
- MRC [G0900806] Funding Source: UKRI
Classical views of the medial temporal lobe (MTL) have established that it plays a crucial role in long-term memory (LTM). Here we demonstrate, in a sample of patients who have undergone anterior temporal lobectomy for the treatment of pharmacoresistant epilepsy, that the MTL additionally plays a specific, causal role in short-term memory (STM). Patients (n=22) and age-matched healthy control participants (n=26) performed a STM task with a sensitive continuous report measure. This paradigm allowed us to examine recall memory for object identity, location and object-location binding, independently on a trial-by-trial basis. Our findings point to a specific involvement of MTL in object-location binding, but, crucially, not retention of either object identity or location. Therefore the MTL appears to perform a specific computation: binding disparate features that belong to a memory. These results echo findings from previous studies, which have identified a role for the MTL in relational binding for LTM, and support the proposal that MTL regions perform such a function for both STM and LTM, independent of the retention duration. Furthermore, these findings and the methodology employed here may provide a simple, sensitive and clinically valuable means to test memory dysfunuction in MTL disorders.
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