期刊
HIPPOCAMPUS
卷 23, 期 9, 页码 751-785出版社
WILEY
DOI: 10.1002/hipo.22141
关键词
convergence; divergence; big data; synapses; boutons
资金
- National Institutes of Health [NS35915]
- National Science Foundation [DGE-0808392]
In this work, through a detailed literature review, data-mining, and extensive calculations, we provide a current, quantitative estimate of the cellular and synaptic constituents of the CA1 region of the rat hippocampus. Beyond estimating the cell numbers of GABAergic interneuron types, we calculate their convergence onto CA1 pyramidal cells and compare it with the known input synapses on CA1 pyramidal cells. The convergence calculation and comparison are also made for excitatory inputs to CA1 pyramidal cells. In addition, we provide a summary of the excitatory and inhibitory convergence onto interneurons. The quantitative knowledge base assembled and synthesized here forms the basis for data-driven, large-scale computational modeling efforts. Additionally, this work highlights specific instances where the available data are incomplete, which should inspire targeted experimental projects toward a more complete quantification of the CA1 neurons and their connectivity. (c) 2013 Wiley Periodicals, Inc.
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