期刊
HIPPOCAMPUS
卷 22, 期 5, 页码 942-953出版社
WILEY-BLACKWELL
DOI: 10.1002/hipo.20950
关键词
postsynaptic density; AMPA receptor; NMDA receptor; quantification
资金
- Grants-in-Aid for Scientific Research [23590273] Funding Source: KAKEN
The postsynaptic density (PSD) protein complex has long been a major target of proteomics in neuroscience. As the number of glutamate receptors on a synapse is one of the main determinants of synaptic efficacy, determining the absolute numbers of receptors in the PSD is necessary for estimating the amplitude of the excitatory postsynaptic current (EPSC) in individual synapses. Moreover, as the receptor molecules are embedded in a macromolecular complex within the PSD, stoichiometry between the receptors and other PSD proteins could help explain the functional and regional specialization of the synapses and their possible roles in synaptic plasticity. Here, I review various studies concerned with the quantification of PSD proteins. (C) 2011 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据