期刊
HIPPOCAMPUS
卷 21, 期 7, 页码 694-701出版社
WILEY-BLACKWELL
DOI: 10.1002/hipo.20833
关键词
hippocampus; CA3; subiculum; fMRI; encoding; retrieval; spatial learning
资金
- National Institute of Mental Health [5T32 MH015795, F32 NS50067-03, NIDA 5T90DA022768-02]
- Northern Piedmont Community Foundation
- Northstar Fund
- Brain Mapping Medical Research Organization
- Brain Mapping Support Foundation
- Pierson-Lovelace Foundation
- Ahmanson Foundation
- Tamkin Foundation
- Jennifer Jones-Simon Foundation
- Capital Group Companies Charitable Foundation
- Robson Family
Although the hippocampus is critical for the formation and retrieval of spatial memories, it is unclear how subregions are differentially involved in these processes. Previous high-resolution functional magnetic resonance imaging (fMRI) studies have shown that CA2, CA3, and dentate gyrus (CA23DG) regions support the encoding of novel associations, whereas the subicular cortices support the retrieval of these learned associations. Whether these subregions are used in humans during encoding and retrieval of spatial information has yet to be explored. Using high-resolution fMRI (1.6 mm x 1.6-mm in-plane), we found that activity within the right CA23DG increased during encoding compared to retrieval. Conversely, right subicular activity increased during retrieval compared to encoding of spatial associations. These results are consistent with the previous studies illustrating dissociations within human hippocampal subregions and further suggest that these regions are similarly involved during the encoding and retrieval of spatial information. (C) 2010 Wiley-Liss, Inc.
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