期刊
HIPPOCAMPUS
卷 21, 期 12, 页码 1263-1267出版社
WILEY-BLACKWELL
DOI: 10.1002/hipo.20875
关键词
17 ss-estradiol; estrogen receptors; hippocampus; synaptogenesis; confocal imaging
资金
- Swiss Science Foundation
- European project Promemoria
- European project Synscaff [31-105721]
Estrogens regulate dendritic spine density, but the mechanism and significance of this effect for brain networks remain unknown. We used repetitive imaging over several days to investigate how 17 beta-estradiol affected the turnover and long-term behavior of dendritic spines in CA1 cells of hippocampal slice cultures. We find that 17 beta-estradiol and serum in the culture medium tightly regulated spine density by promoting an increase in the rate of new spine formation and their transformation into synapses, without affecting spine elimination or stability. New spines formed during a transient 17 beta-estradiol application were preferentially eliminated upon removal of the hormone, in contrast with pre-existing spines that remained unaffected. Our results reveal that 17 beta-estradiol transiently regulates the complexity of hippocampal circuits without causing major alterations of pre-existing networks. (C) 2010 Wiley Periodicals, Inc.
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