期刊
HIPPOCAMPUS
卷 19, 期 10, 页码 1002-1007出版社
WILEY
DOI: 10.1002/hipo.20564
关键词
L1 retrotransposition; LINE-1; voluntary exercise; new environment; neurogenesis; neuronal diversity
资金
- The Rett Syndrome Research Foundation
- The McDonnell Foundation
- The George E. Hewitt Foundation for Medical Research
- The Lookout Fund
- The Picower Foundation
- The National Institutes of Health (National Institute on Aging and National Institute of Neurological Disease and Stroke)
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH088485] Funding Source: NIH RePORTER
It is well established that neuronal circuits can be shaped by experience. Neuronal plasticity can be achieved by synaptic competitive interactions and the addition of new neuronal units in neurogenic regions of the adult brain. Recent data have suggested that neuronal progenitor cells can accommodate somatic LINE-1 (Long Interspersed Nuclear Elements-1 or L1) retrotransposition. Genomic L1 insertions may up- or down-regulate transcriptional control of gene expression. Here, we show that exercise has a positive effect on a L1-EGFP reporter in vivo. We found that neurons from mice that experience voluntary exercise are more likely to activate an EGFP reporter marker, representing L1 insertions in the brain, when compared with sedentary animals. In the hippocampus, a neurogenic region of the adult brain, EGFP expression is mainly found in cells localized in the subgranular layer of the dentate gyros. This observation implies that neuronal progenitor cells may support de novo retrotransposition upon exposure to a new environment. Such evidence suggests that experience-dependent L1 retrotransposition may contribute to the physiological consequences of neuronal plasticity. (C) 2009 Wiley-Liss, Inc.
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