期刊
HIPPOCAMPUS
卷 18, 期 7, 页码 699-709出版社
WILEY
DOI: 10.1002/hipo.20429
关键词
dorsal fornix; fimbria; acetylcholine (ACh); encoding and retrieval; maze learning; animal cognition; computational model; learning and memory
资金
- NIMH NIH HHS [R01MH065314] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH065314] Funding Source: NIH RePORTER
CA3 lesions impair encoding, whereas CA1 lesions impair retrieval during learning of a Hebb-Williams maze. CA3 efferents in the fimbria were transected, taking care to spare cholinergic and GABAergic afferents. CA1 efferents in the dorsal fornix were similarly transected. Fimbria transections, but not dorsal fornix transections, resulted in deficits for the encoding of spatial information during learning of a Hebb-Williams maze. Dorsal fornix, but not fimbria, transections resulted in deficits for retrieval of spatial memory during learning of a Hebb-Williams maze. These results reveal a double dissociation for the roles of CA3 and CA1 subcortical efferents in encoding and retrieval processes that mirror the double dissociation seen after excitotoxic lesions of CA1 and CA3. These data provide support for the theory that the cholinergic projections from the septal nuclei modulate the dynamics for encoding and consolidation/retrieval in the hippocampus. (C) 2008 Wiley-Liss, Inc.
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