期刊
HIPPOCAMPUS
卷 18, 期 9, 页码 955-964出版社
WILEY
DOI: 10.1002/hipo.20455
关键词
dorsal CA3; dorsal CA1; dorsal dentate gyrus; temporal processing; episodic memory; spatial pattern separation; spatial memory; associative memory
资金
- NSF [IBN-0135273]
- NIH [RO1MH065314]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH065314] Funding Source: NIH RePORTER
It has been demonstrated that the dorsal CA1 subregion of the hippocampus mediates temporal processing of information, that dorsal CA3 participates in the spatiotemporal processing of memory, and the dorsal dentate gyrus (DG) mediates spatial pattern separation. A temporal ordering of spatial locations task was developed to test the role of the dorsal DG, CA3, and CA1 for the temporal processing of spatial information with either high or low levels of spatial interference. The results indicate that animals with DG lesions showed difficulty performing the task at high levels of spatial interference, but were able to perform the task well when there was low spatial interference. Animals with lesions to CA3 did not show a preference for either spatial location presented during the study phase during the preference test, suggesting impaired spatiotemporal processing. Animals with lesions to CA1 showed a preference for a later presented spatial location over the earlier, the opposite preference to that shown by control animals. (C) 2008 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据