期刊
HFSP JOURNAL
卷 3, 期 4, 页码 223-227出版社
HFSP PUBLISHING
DOI: 10.2976/1.3185785
关键词
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资金
- Alvin and Gertrude Levine Career Development Chair
Collective motion of cell cultures is a process of great interest, as it occurs during morphogenesis, wound healing, and tumor metastasis. During these processes cell cultures move due to the traction forces induced by the individual cells on the surrounding matrix. A recent study [Trepat, et al., 2009.. Nat. Phys. 5, 426-430] measured for the first time the traction forces driving collective cell migration and found that they arise throughout the cell culture. The leading 5-10 rows of cell do play a major role in directing the motion of the rest of the culture by having a distinct outwards traction. Fluctuations in the traction forces are an order of magnitude larger than the resultant directional traction at the culture edge and, furthermore, have an exponential distribution. Such exponential distributions are observed for the sizes of adhesion domains within cells, the traction forces produced by single cells, and even in nonbiological nonequilibrium systems, such as sheared granular materials. We discuss these observations and their implications for our understanding of cellular flows within a continuous culture. [DOI: 10.2976/1.3185785]
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