4.2 Article

INTRODUCING THE DIELS-ALDER REACTIVITY OF 2-FURANMETHANETHIOL WITH SELECTED MALEIC ACID DERIVATIVES

期刊

HETEROCYCLES
卷 88, 期 2, 页码 1603-1613

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-13-S(S)112

关键词

-

资金

  1. Natural Sciences and Engineering Research Council of Canada
  2. Ontario government

向作者/读者索取更多资源

Surprising chemoselectivity is demonstrated in the reaction of 2-furanmethanethiol with maleic anhydride and with N-phenylmaleimide. These maleic acid derivatives demonstrate a predilection for Die Is-Alder cycloaddition, forgoing both conjugate addition and initial carbonyl attack. N-Ethylmaleimide showed a preference for conjugate addition, whereas diethyl fumarate or dimethyl maleate proved unreactive. The cycloadduct of 2-furanmethanethiol and maleic anhydride was subjected to dehydration/aromatization conditions to create benzo[c]thiophen-1(3H)-one-7-carboxylic acid. An alkylation attempt also led to the foimation of a thiolester.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据