期刊
HETEROCYCLES
卷 88, 期 2, 页码 1603-1613出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-13-S(S)112
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-
资金
- Natural Sciences and Engineering Research Council of Canada
- Ontario government
Surprising chemoselectivity is demonstrated in the reaction of 2-furanmethanethiol with maleic anhydride and with N-phenylmaleimide. These maleic acid derivatives demonstrate a predilection for Die Is-Alder cycloaddition, forgoing both conjugate addition and initial carbonyl attack. N-Ethylmaleimide showed a preference for conjugate addition, whereas diethyl fumarate or dimethyl maleate proved unreactive. The cycloadduct of 2-furanmethanethiol and maleic anhydride was subjected to dehydration/aromatization conditions to create benzo[c]thiophen-1(3H)-one-7-carboxylic acid. An alkylation attempt also led to the foimation of a thiolester.
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