期刊
HETEROCYCLES
卷 85, 期 3, 页码 587-613出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/REV-12-727
关键词
Aspergillide; Macrolide; Tetrahydropyran; Oxa-Michael Addition; Marine Natural Product
资金
- Grants-in-Aid for Scientific Research [22380064, 10J05127] Funding Source: KAKEN
Aspergillides A, B, and C are cytotoxic macrolides produced by the marine-derived fungus Aspergillus ostiunus strain TUF 01F313. The unique molecular architectures of the aspergillides featuring 14-membered marocyclic structures embedded with a tetrahydro- or dihydropyran unit have attracted significant attention from the synthetic chemistry community, and thereby various synthetic approaches to these structurally as well as pharmacologically intriguing molecules have been reported by as many as 12 research groups in the past 3 years. This review describes all of the syntheses disclosed to date, focusing mainly on the methodologies employed for the diastereoselective installation of the pyran ring systems.
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