期刊
HETEROCYCLES
卷 78, 期 5, 页码 1309-1316出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-08-11630
关键词
Citrus medica L. var. sarcodactylis Swingle; Rutaceae; Biscoumarin; Citrumedin-A
资金
- National Science Council, R. O. C. [NSC 91-2113-M-273-001]
A new biscoumarin, namely citrumedin-A [6,6',7,7'-tetramethoxy-3,3'-biscoumarin] (1), together with twenty two known compounds were isolated from the stem bark of Citrus medica L. var. sarcodactylis Swingle. The structure of this new compound was completely elucidated using a combination of 2D NMR techniques (COSY, NOESY, HMQC and HMBC) and HR-EI-MS analyses. The known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literatures. The isolates were also screened their cytotoxicity against Daoy, Hep2, MCF-7 and Hela cell lines. Lonchocarpol A (12) showed marginally cytotoxic activity against those four cancer cell lines.
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