期刊
HETEROCYCLES
卷 78, 期 2, 页码 369-387出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-08-11508
关键词
Amino-Heck Reaction; Pyridine; Phosphinyloxime; Palladium; Aza-Heterocyle
资金
- National Science Council of Republic of China (Taiwan)
- National Dong-Hwa University
The amino-Heck cyclization process has been applied into a range of gamma,delta-unsaturated ketone O-diethylphosphinyloximes 1 and delta,epsilon-unsaturated ketone O-diethylphosphinyloximes 7. Under the specific catalytic conditions developed by us, these substrates were found to preferentially undergo the 6-endo cyclization to give the formation of 2-substituted pyridines 3 and substituted methylpyridines 8, respectively, in moderate to good yields. Besides, several interesting aspects on the effects of phosphinyl groups, solvents, bases and molecular sieves on the regioselectivity of the cyclization of 1 have also been realized.
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