期刊
HETEROCYCLES
卷 77, 期 2, 页码 849-854出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-08-S(F)111
关键词
6-Azapurine; Toxoflavin; Transformation; 7-Azapteridine; Rearrangement
This paper describes a reliable and facile synthesis of 6-azapurines (1,5-dimethyl-1H-imidazo[4,5-e][1,2,4]triazin-6(5H)-ones) by treatment of toxoflavins (7-azapteridines) with 10% aqueous sodium hydroxide at 5-25 degrees C along with a benzilic acid type rearrangement, followed by decarboxylation and oxidation by air. Furthermore, heating the 6-azapurines in 10% ethanolic sodium hydroxides afforded the corresponding 1,2,4-triazine-5,6(1H,4H)-diones to be caused by ring fission of the imidazole of 6-azapurines.
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