Syntheses, Characterizations, Crystal structures, and Antitumor Activities of Arenetelluronic Triorganotin Esters

Six new arenetelluronic triorganotin esters, namely (R3Sn)(4)[ArTe(mu-O)(OH)O-2)](2) (Ar = Ph, R = Me: 1, R = Ph: 2; Ar = 3-Me-Ph, R = Me: 3, R = Ph: 4, Ar = 3-Cl-Ph, R = Me: 5, R = Ph: 6), were prepared by treating arenetelluronic acids with the corresponding R3SnCl (R = Me, Ph) with potassium hydroxide in methanol. All complexes were characterized by elemental analysis, FT-IR, NMR (H-1, C-13, Sn-119) spectroscopy, and X-ray crystallography. The structural analyses indicate that these complexes are isostructural as Sn4Te2 moiety, in which the Te-2(mu(2)-O)(2) units are situated in the center and each Te atom is coordinated with two OSnR3 groups on the side. Complexes 1, 3, and 5 show one-dimensional chain and two-dimensional network supramolecular structures by intermolecular C-H...O or C-H...Cl interactions. The antitumor activities of these complexes reveal that most arenetelluronic triorganotin esters have powerful antitumor activities with certain regularity. (c) 2014 Wiley Periodicals, Inc.