期刊
HEREDITY
卷 108, 期 5, 页码 480-489出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/hdy.2011.119
关键词
parallel sequence evolution; bats; high-frequency hearing
资金
- Genome Centre of the Barts
- London School of Royal Medicine and Dentistry
- Natural Environmental Research Council (UK)
- Central Research Fund (London)
- Systematic Research Fund
- Science Foundation Ireland PIYRA
- RCUK
- Royal Society
Recent findings of sequence convergence in the Prestin gene among some bats and cetaceans suggest that parallel adaptations for high-frequency hearing have taken place during the evolution of echolocation. To determine if this gene is an exception, or instead similar processes have occurred in other hearing genes, we have examined Tmc1 and Pjvk, both of which are associated with non-syndromic hearing loss in mammals. These genes were amplified and sequenced from a number of mammalian species, including echolocating and non-echolocating bats and whales, and were analysed together with published sequences. Sections of both genes showed phylogenetic signals that conflicted with accepted species relationships, with coding regions uniting laryngeal echolocating bats in a monophyletic clade. Bayesian estimates of posterior probabilities of convergent and divergent substitutions provided more direct evidence of sequence convergence between the two groups of laryngeal echolocating bats as well as between echolocating bats and dolphins. We found strong evidence of positive selection acting on some echolocating bat species and echolocating cetaceans, contrasting with purifying selection on non-echolocating bats. Signatures of sequence convergence and molecular adaptation in two additional hearing genes suggest that the acquisition of high-frequency hearing has involved multiple loci. Heredity (2012) 108, 480-489; doi:10.1038/hdy.2011.119; published online 14 December 2011
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