期刊
HEREDITY
卷 105, 期 1, 页码 24-37出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/hdy.2010.49
关键词
epigenetics; histone lysine methylation; heterochromatin; mouse development
资金
- Center of Integrated Protein Science Munich
- Friedrich Baur-Stiftung
Epigenetic mechanisms contribute to the establishment and maintenance of cell-type-specific gene expression patterns. In this review, we focus on the functions of histone lysine methylation in the context of epigenetic gene regulation during developmental transitions. Over the past few years, analysis of histone lysine methylation in active and repressive nuclear compartments and, more recently, genome-wide profiling of histone lysine methylation in different cell types have revealed correlations between particular modifications and the transcriptional status of genes. Identification of histone methyltransferases (HMTases) and specific binding factors for most methylated lysine positions has provided a novel insight into the mechanisms of epigenetic gene regulation. In addition, analyses of HMTase knockout mice show that histone lysine methylation has important functions for normal development. In this study, we review mechanisms of gene activation and repression by histone lysine methylation and discuss them in the context of the developmental roles of HMTases. Heredity (2010) 105, 24-37; doi:10.1038/hdy.2010.49; published online 5 May 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据