期刊
HEREDITY
卷 105, 期 1, 页码 122-134出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/hdy.2010.27
关键词
adult neurogenesis; dynamic methylation; histone methylation; DNA methylation; epigenetic modifications; hippocampus
资金
- European Science Foundation [DFG 858/6-2]
- Marie Curie Excellence Team Program
- European Union
- Bavarian Research Network on Adult Neural Stem Cells 'FOR-NEUROCELL'
- Helmholtz Alliance for Mental Health in an Aging Society
- BMBF Network 'Cell Based Regenerative Medicine'
- European Commission [LSHM-CT-2005-19063]
The dentate gyrus of the hippocampus is an exception to a 'neurogenesis-unfriendly' environment of the adult brain. New functional neurons generated in this region contribute to learning and mood regulation, and thus represent a unique form of neural plasticity. The rate of hippocampal neurogenesis significantly changes on physiological or pathological influences, such as physical activity, environmental enrichment, stress, and aging. We suggest that epigenetic mechanisms could be sensors of environmental changes and fine modulators of adult hippocampal neurogenesis. Here, we examine the role of DNA methylation and methylation of core histones mediated by the Polycomb and Trithorax complexes in the regulation of adult neurogenesis. Given the recent surprising discovery of dynamic and reversible DNA methylation in the hippocampus, we speculate regarding its regulation and its role in adult neurogenesis. Heredity (2010) 105, 122-134; doi:10.1038/hdy.2010.27; published online 24 March 2010
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