期刊
HEREDITY
卷 105, 期 1, 页码 80-91出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/hdy.2010.50
关键词
cell division cycle; chromatin; epigenetics; differentiation; plant; arabidopsis
资金
- Ministry of Science and Innovation [BFU2009-9783, CSD2007-00057-B]
- Comunidad de Madrid [P2006/GEN-0191]
- Fundacion Ramon Areces
Eukaryotic chromatin is a highly structured macromolecular complex of which DNA is wrapped around a histone-containing core. DNA can be methylated at specific C residues and each histone molecule can be covalently modified at a large variety of amino acids in both their tail and core domains. Furthermore, nucleosomes are not static entities and both their position and histone composition can also vary. As a consequence, chromatin behaves as a highly dynamic cellular component with a large combinatorial complexity beyond DNA sequence that conforms the epigenetic landscape. This has key consequences on various developmental processes such as root and flower development, gametophyte and embryo formation and response to the environment, among others. Recent evidence indicate that posttranslational modifications of histones also affect cell cycle progression and processes depending on a correct balance of proliferating cell populations, which in the context of a developing organisms includes cell cycle, stem cell dynamics and the exit from the cell cycle to endoreplication and cell differentiation. The impact of epigenetic modifications on these processes will be reviewed here. Heredity (2010) 105, 80-91; doi:10.1038/hdy.2010.50; published online 28 April 2010
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