期刊
HEPATOLOGY INTERNATIONAL
卷 4, 期 3, 页码 577-584出版社
SPRINGER
DOI: 10.1007/s12072-010-9197-z
关键词
Hepatitis B virus; Enhancer II; Core promoter; Precore; X genes; Hepatocellular carcinoma
资金
- Thailand Research Fund
- Center of Excellence in Clinical Virology, Chulalongkorn University, Bangkok, Thailand
To evaluate the sequence variations in the enhancer II (EnhII)/basal core promotor (BCP)/precore (PC) and X genes of hepatitis B virus (HBV) in Thai patients with hepatocellular carcinoma (HCC) by conducting a cross-sectional case-control study. As much as 60 patients with HCC and 60 patients without HCC, who were matched for sex, age, hepatitis B e antigen (HBeAg) status, and HBV genotype, were included. Viral mutations in the EnhII/BCP/PC and X regions were characterized by direct sequencing in serum samples. The prevalence of T1753C/A, A1762T/G1764A and G1899A mutations were significantly higher in the HCC group compared to the non-HCC group (43.3 vs. 23.3%, P = 0.02; 88.3 vs. 53.0%, P < 0.001; and 35.0 vs. 8.3%, P = 0.001, respectively). No significant difference between groups was found with respect to G1613A, C1653T, C1766T/T1768A, A1846T/C, T1858C, and G1896A mutations. By multiple logistic regression analysis, the presence of cirrhosis, A1762T/G1764A and G1899A mutations were independently associated with the risk of HCC. These data suggested that A1762T/G1764A and G1899A mutations were associated with the development of HCC in Thai patients.
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