期刊
LANCET NEUROLOGY
卷 14, 期 4, 页码 443-454出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(14)70294-7
关键词
-
资金
- Bayer Schering
- Biogen Idec
- Merck Serono
- Novartis
- TEVA Neurosciences
- Italian Ministry of Health
- AriSLA-Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica
- Fondazione Italiana Sclerosi Multipla
- Bayer Schering Pharma
- Teva Pharmaceutical Industries
- Cure PSP
- Alzheimer's and Drug Discovery Foundation
- Jacques and Gloria Gossweiler Foundation (Switzerland)
- Wellcome Trust
- MS Society of Great Britain and Northern Ireland
- UCL Biomedical Research Centre
- Engineering and Physical Sciences Research Council
- Actelion
- Addex
- Advancell
- Allozyne
- BaroFold
- Bayer Health Care Pharmaceuticals
- Bayhill
- Biotica
- CLC Behring
- Elan
- Genentech
- GeNeuro SA
- Genmab
- Genmark
- Genzyme
- GlaxoSmithKline
- Johnson Johnson
- Lilly
- Mitsubishi Pharma
- Novo Nordisk
- Octapharma
- Peptimmune
- Praxicon
- Roche
- Sanofi-Aventis
- Santhera
- Siemens
- Teva
- UCB
- Xenoport
- Wyeth
- MRC [G0700238] Funding Source: UKRI
- Medical Research Council [G0700238] Funding Source: researchfish
The spinal cord is a clinically important site that is affected by pathological changes in most patients with multiple sclerosis; however, imaging of the spinal cord with conventional MRI can be difficult. Improvements in MRI provide a major advantage for spinal cord imaging, with better signal-to-noise ratio and improved spatial resolution. Through the use of multiplanar MRI, identification of diffuse and focal changes in the whole spinal cord is now routinely possible. Corroborated by related histopathological analyses, several new techniques, such as magnetisation transfer, diffusion tension imaging, functional MRI, and proton magnetic resonance spectroscopy, can detect non-focal, spinal cord pathological changes in patients with multiple sclerosis. Additionally, functional MRI can reveal changes in the response pattern to sensory stimulation in patients with multiple sclerosis. Through use of these techniques, findings of cord atrophy, intrinsic cord damage, and adaptation are shown to occur largely independently of focal spinal cord lesion load, which emphasises their relevance in depiction of the true burden of disease. Combinations of magnetisation transfer ratio or diffusion tension imaging indices with cord atrophy markers seem to be the most robust and meaningful biomarkers to monitor disease evolution in early multiple sclerosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据