相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma
Diego F. Calvisi et al.
GASTROENTEROLOGY (2011)
Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer
Diego F. Calvisi et al.
JOURNAL OF HEPATOLOGY (2011)
Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis
Alyssa L. Kennedy et al.
MOLECULAR CELL (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
The role of signaling pathways in the development and treatment of hepatocellular carcinoma
S. Whittaker et al.
ONCOGENE (2010)
Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis
Chuan-Rui Xu et al.
MOLECULAR CANCER RESEARCH (2009)
Targeted therapy for hepatocellular carcinoma
Hans Christian Spangenberg et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2009)
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated Raptor phosphorylation
Audrey Carriere et al.
CURRENT BIOLOGY (2008)
Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma
Augusto Villanueva et al.
GASTROENTEROLOGY (2008)
Activated kras, but not hras or nras, may initiate tumors of endodermal origin via stem cell expansion
Margaret P. Quinlan et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
The splicing-factor oncoprotein SF2/ASF activates mTORC1
Rotem Karni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1
Jidong Zhu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP:: tipping the scales of cancer
David Frescas et al.
NATURE REVIEWS CANCER (2008)
Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition
M. S. Song et al.
ONCOGENE (2008)
Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer
Susie A. Lee et al.
HEPATOLOGY (2008)
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma
Diego F. Calvisi et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Hyperactive Ras in developmental disorders and cancer
Suzanne Schubbert et al.
NATURE REVIEWS CANCER (2007)
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
DF Calvisi et al.
GASTROENTEROLOGY (2006)
Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling
YW Lin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Forkhead box m1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase
IC Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse
CM Carlson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A conditional feedback loop regulates Ras activity through EphA2
M Macrae et al.
CANCER CELL (2005)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
I Vivanco et al.
NATURE REVIEWS CANCER (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)