相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Oral Medications with Significant Hepatic Metabolism at Higher Risk for Hepatic Adverse Events
Craig Lammert et al.
HEPATOLOGY (2010)
Pharmacogenetics: from discovery to patient care
Jaekyu Shin et al.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2009)
A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran
Ulf Andersson et al.
BIOMARKERS (2009)
Impact of OATP transporters on pharmacokinetics
A. Kalliokoski et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity
Stefan Russmann et al.
CURRENT MEDICINAL CHEMISTRY (2009)
Genetic Variations of the ABC Transporter Gene ABCB11 Encoding the Human Bile Salt Export Pump (BSEP) in a Japanese Population
Su-Ryang Kim et al.
DRUG METABOLISM AND PHARMACOKINETICS (2009)
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans
Alison H. Harrill et al.
GENOME RESEARCH (2009)
Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy
P. H. Dixon et al.
GUT (2009)
Hepatic OATP1B Transporters and Nuclear Receptors PXR and CAR: Interplay, Regulation of Drug Disposition Genes, and Single Nucleotide Polymorphisms
Henriette E. Meyer Zu Schwabedissen et al.
MOLECULAR PHARMACEUTICS (2009)
HLA-B☆5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
Ann K. Daly et al.
NATURE GENETICS (2009)
CURRENT CONCEPTS Genomewide Association Studies and Human Disease
John Hardy et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions
M. R. Nelson et al.
PHARMACOGENOMICS JOURNAL (2009)
Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s
Bo Wen et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2008)
Bioactivation of flutamide metabolites by human liver microsomes
Ping Kang et al.
DRUG METABOLISM AND DISPOSITION (2008)
Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3
Chunshan Gui et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
CYP2E1 and oxidative liver injury by alcohol
Yongke Lu et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
Severe bile salt export pump deficiency:: 82 different ABCB11 mutations in 109 families
Sandra S. Strautnieks et al.
GASTROENTEROLOGY (2008)
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-induced Liver Injury in the United States
Naga Chalasani et al.
GASTROENTEROLOGY (2008)
Glutathione S-transferase M1 and T1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury
M. Isabel Lucena et al.
HEPATOLOGY (2008)
Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals
Craig Lammert et al.
HEPATOLOGY (2008)
Haplotypic analysis of wellcome trust case control consortium data
Brian L. Browning et al.
HUMAN GENETICS (2008)
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
Paul I. W. de Bakker et al.
HUMAN MOLECULAR GENETICS (2008)
Analysis of IL-10, IL-4 and TNF-α polymorphisms in drug-induced liver injury (DILI) and its outcome
Ketevan Pachkoria et al.
JOURNAL OF HEPATOLOGY (2008)
Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans
Peter Kovacs et al.
JOURNAL OF HEPATOLOGY (2008)
Influence of glutathione S-transferase M1 and T1 homozygous null mutations on the risk of antituberculosis drug-induced hepatotoxicity in a Caucasian population
Virginia Leiro et al.
LIVER INTERNATIONAL (2008)
SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study
NEW ENGLAND JOURNAL OF MEDICINE (2008)
HLA-B*5701 screening for hypersensitivity to abacavir
Simon Mallal et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
The Role of FXR in Disorders of Bile Acid Homeostasis
Jyrki J. Eloranta et al.
PHYSIOLOGY (2008)
Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney
Zoulikha M. Zaier et al.
PHARMACOGENOMICS (2008)
The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity
Ian M. Copple et al.
TOXICOLOGY (2008)
Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump
Yvonne Meier et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family
B. Hagenbuch et al.
XENOBIOTICA (2008)
Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis
A. Kindmark et al.
PHARMACOGENOMICS JOURNAL (2008)
Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1l2 and their association with CYP3A4 expression
Jatinder Lamba et al.
DRUG METABOLISM AND DISPOSITION (2008)
Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity
Daniel F. Carr et al.
PHARMACOGENETICS AND GENOMICS (2007)
Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy
Saskia W. C. Van Mil et al.
GASTROENTEROLOGY (2007)
A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression
Catia Marzolini et al.
MOLECULAR ENDOCRINOLOGY (2007)
Delayed drug hypersensitivity reactions - new concepts
S. J. Posadas et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2007)
Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H:quinone oxidoreductase, glutathione S-transferase M1 and T1, and the susceptibility to drug-induced liver injury
Yi-Shin Huang et al.
JOURNAL OF HEPATOLOGY (2007)
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
Paul R. Burton et al.
NATURE (2007)
MRP2 haplotypes confer differential susceptibility to toxic liver injury
Ji Ha Choi et al.
PHARMACOGENETICS AND GENOMICS (2007)
Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities
Michie M. K. Ong et al.
TOXICOLOGICAL SCIENCES (2007)
Genetic polymorphisms of CYP2C9 and CYP2C19 are not related to drug-induced idiosyncratic liver injury (DILI)
K. Pachkoria et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
The bile salt export pump
Bruno Stieger et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Genetic polymorphisms of drug-metabolizing enzymes and the susceptibility to antituberculosis drug-induced liver injury
Yi-Shin Huang
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2007)
Mitochondrial abnonnalities - A link to idiosyncratic drug hepatotoxicity?
Urs A. Boelsterli et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2007)
Genetic susceptibility to diclofenac-induced hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 genotypes
Ann K. Daly et al.
GASTROENTEROLOGY (2007)
Perhexiline
Houman Ashrafian et al.
CARDIOVASCULAR DRUG REVIEWS (2007)
Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury
Carmen Lang et al.
PHARMACOGENETICS AND GENOMICS (2007)
Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart
Markus Grube et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2006)
Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
Yvonne Meier et al.
HEPATOLOGY (2006)
Observations of alanine aminotransferase and aspartate aminotransferase in THRIVE studies treated orally with ximelagatran
Job Harenberg et al.
INTERNATIONAL JOURNAL OF TOXICOLOGY (2006)
'Hy's Law,' the 'Rezulin Rule,' and other predictors of severe drug-induced hepatotoxicity: putting risk-benefit into perspective
JH Lewis
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2006)
Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2+/- mice
MMK Ong et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: Cohort study using data from the UK General Practice Research Database
S Russmann et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2005)
Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells
Y Kameyama et al.
PHARMACOGENETICS AND GENOMICS (2005)
Idiosyncratic drug hepatotoxicity
N Kaplowitz
NATURE REVIEWS DRUG DISCOVERY (2005)
Role of metabolism in drug-induced idiosyncratic hepatotoxicity
JL Walgren et al.
CRITICAL REVIEWS IN TOXICOLOGY (2005)
Hepatic findings in long-term clinical trials of ximelagatran
WM Lee et al.
DRUG SAFETY (2005)
Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice
CEP Goldring et al.
HEPATOLOGY (2004)
Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
GP Aithal et al.
HEPATOLOGY (2004)
Decreased glutathione in patients with anorexia nervosa.: Risk factor for toxic liver injury?
F Zenger et al.
EUROPEAN JOURNAL OF CLINICAL NUTRITION (2004)
Acetaminophen-induced hepatotoxicity: Role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition
JA Hinson et al.
DRUG METABOLISM REVIEWS (2004)
Pharmacogenetics and drug development: The path to safer and more effective drugs
AD Roses
NATURE REVIEWS GENETICS (2004)
Acute and clinically relevant drug-induced liver injury:: a population based case-control study
FJ de Abajo et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Enterohepatic bile salt transporters in normal physiology and liver disease
GA Kullak-Ublick et al.
GASTROENTEROLOGY (2004)
HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease
RJ Andrade et al.
HEPATOLOGY (2004)
Leflunomide-induced acute hepatitis
C Sevilla-Mantilla et al.
DIGESTIVE AND LIVER DISEASE (2004)
Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity
UA Boelsterli
TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)
Pretreatment of chronic active hepatitis C in patients coinfected with HIV and hepatitis C virus reduces the hepatotoxicity associated with subsequent antiretroviral therapy
C Uberti-Foppa et al.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2003)
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus
I Watanabe et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2003)
Cytochrome p450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis
YS Huang et al.
HEPATOLOGY (2003)
Arylamine N-acetyltransferase-2 genotypes in the Thai population
V Kukongviriyapan et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2003)
Fatal liver failure with atorvastatin
L Perger et al.
JOURNAL OF HEPATOLOGY (2003)
Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment
SK Sharma et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)
Incidence of drug-induced hepatic injuries: A French population-based study
C Sgro et al.
HEPATOLOGY (2002)
The structure of haplotype blocks in the human genome
SB Gabriel et al.
SCIENCE (2002)
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis
YS Huang et al.
HEPATOLOGY (2002)
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
S Mallal et al.
LANCET (2002)
Candidate gene case-control association studies: advantages and potential pitfalls
AK Daly et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2001)
Kava hepatotoxicity
S Russmann et al.
ANNALS OF INTERNAL MEDICINE (2001)
Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: Potent inhibition of CYP2C19 and CYP3A
Z Desta et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2001)
Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis
GP Aithal et al.
PHARMACOGENETICS (2000)
Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults
KE Thummel et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2000)
Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity
T Simon et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2000)