期刊
HEPATOLOGY
卷 48, 期 2, 页码 670-678出版社
WILEY-BLACKWELL
DOI: 10.1002/hep.22399
关键词
-
资金
- NIDDK NIH HHS [R01 DK068450-04, R01 DK061510, P30 DK026743, R01 DK068450, P30 DK026743-25S1] Funding Source: Medline
Obesity is an inflammatory disorder characterized by heightened activity of the innate immune system. Innate immune activation is central to the development of obesity-related insulin resistance; it also plays an important role in obesity-related tissue damage, such as that seen in atherosclerosis. Recent research has implicated the innate immune system in the pathophysiology of obesity-related liver disease. This review summarizes how innate immune processes, occurring both within and outside the liver, cause not only insulin resistance but also end-organ damage in the form of nonalcoholic fatty liver disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据