期刊
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
卷 27, 期 1, 页码 89-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2012.11.002
关键词
Chronic granulomatous disease; Gene defects; NADPH oxidase; Immune defect; Inflammatory bowel disease
资金
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Chronic granulomatous disease (CGD) is a paradigm for nonlymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, vasculature, and brain. It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced HIV and before its routine use in neutropenia. It has been an attractive target for gene therapy and bone marrow transplantation for nonmalignant diseases. Therefore, CGD is worthy of attention for its historical interest and because it is a disease for which expert management is imperative.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据