期刊
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
卷 27, 期 1, 页码 1-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2012.11.003
关键词
Congenital neutropenia; Epidemiology; Birth incidence; Prevalence
资金
- Amgen SAS
- Chugai SA
- GIS Maladies Rares
- Institut de Veille Sanitaire
- Inserm
- Association Laurette Fugain
- Association Sportive de Saint Quentin Fallavier
- Societe d'Hemato Immunologie Pediatrique
Epidemiology of Congenital Neutropenia Jean Donadieu, Blandine Beaupain, Nizar Mahlaoui, and Christine Bellanne-Chantelot Epidemiologic investigations of congenital neutropenia aim to determine several important indicators related to the disease, such as incidence at birth, prevalence, and outcome in the population, including the rate of severe infections, leukemia, and survival. Genetic diagnosis is an important criterion for classifying patients and reliably determining the epidemiologic indicators. Patient registries were developed in the 1990s. The prevalence today is probably more than 10 cases per million inhabitants. The rate of infection and leukemia risk can now be calculated. Risk factors for leukemia seem to depend on both the genetic background and cumulative dose of granulocyte colony stimulating factor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据