期刊
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
卷 26, 期 5, 页码 1065-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2012.07.007
关键词
Myeloproliferative neoplasms; Preclinical murine models; BCR-ABL; JAK2V617F; Hematopoietic stem cells; Bone marrow microenvironment; Myelofibrosis; Oncogenes
资金
- NCI NIH HHS [P01 CA066996] Funding Source: Medline
- NHLBI NIH HHS [R01 HL082945, K08 HL109734] Funding Source: Medline
Myeloproliferative neoplasm (MPN) animal models accurately re-capitulate human disease in mice and have been an important tool for the study of MPN biology and therapy. Transplantation of BCR-ABL transduced bone marrow into irradiated syngeneic mice established the field of MPN animal modeling. Genetically engineered MPN animal models have enabled detailed characterization of the effects of specific MPN-associated genetic abnormalities on hematopoietic stem and progenitor cells (HSPCs). Xenograft models have allowed the study of primary human MPN-propagating cells in vivo. JAK2V617F, the most common molecular abnormality in BCR-ABL negative MPN, has been extensively studied using retroviral, transgenic, knock-in and xenograft models.
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