4.2 Article

Protein Quality Control During Erythropoiesis and Hemoglobin Synthesis

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出版社

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2010.08.013

关键词

Hemoglobin; Thalassemia; Protein quality control

资金

  1. National Institutes of Health [5R01HL087427 04, 5R01DK061692 08, 3T32GM007170 35S1]
  2. Cooley s Anemia Foundation

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Erythrocytes must regulate hemoglobin synthesis to limit the toxicities of unstable free globin chain subunits This regulation is particularly relevant in beta-thalassemia, in which beta-globin deficiency causes accumulation of free alpha-globin which forms intracellular precipitates that destroy erythroid precursors Experimental evidence accumulated over more than 40 years indicates that erythroid cells can neutralize moderate amounts of free alpha-globin through generalized protein quality control mechanisms including molecular chaperones, the ubiquitin-proteasome system and autophagy In many ways beta-thalassemia resembles protein aggregation disorders of the nervous system, liver and other tissues, which occur when levels of unstable proteins overwhelm cellular compensatory mechanisms Information gained from studies of nonerythroid protein aggregation disorders may be exploited to further understand and perhaps treat beta-thalassemia

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