期刊
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
卷 24, 期 2, 页码 343-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2010.02.008
关键词
Innate immunity; Myelodysplastic syndromes; Acute myeloid leukemia; MicroRNAs; Toll-like receptor; NF-kappa B
资金
- Canadian Institutes of Health Research [MOP 89976]
Myelodysplastic syndromes (MDS) are heterogeneous clonal hematologic malignancies characterized by cytopenias caused by ineffective hematopoiesis and propensity to progress to acute myeloid leukemia. Innate immunity provides immediate protection against pathogens by coordinating activation of signaling pathways in immune cells. Given the prominent role of the innate immune pathway in regulating hematopoiesis, it is not surprising that aberrant signaling of this pathway is associated with hematologic malignancies. Increased activation of the innate immune pathway may contribute to dysregulated hematopoiesis, dysplasia, and clonal expansion in myelodysplastic syndromes.
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