期刊
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
卷 23, 期 5, 页码 991-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2009.07.001
关键词
Acute lymphoblastic leukemia; Gene mutations; Chromosome aberrations; Human; Prognosis
资金
- NIH
- NCI [CA101140, CA16058]
- Coleman Leukemia Research Foundation
- NATIONAL CANCER INSTITUTE [P30CA016058, U10CA101140, ZIASC010378, ZIASC010379] Funding Source: NIH RePORTER
Acute lymphoblastic leukemia (ALL) is a malignant disease that often features nonrandom numerical or structural chromosome aberrations that can be detected microscopically. The application of contemporary genome-wide molecular analyses is revealing additional genetic alterations that are not detectable cytogenetically. This article describes the cytogenetic methodology and summarizes major cytogenetic findings and their clinical relevance in ALL. The article provides a review of modern molecular techniques and their application in the research on the genetics and epigenetics of ALL.
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